Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC035
Test administered by neuromedic@manusdevices.net
Test date and time 2023-01-16 11:44
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 4x1/2 caps Madopar a 125mg 2 uvece tbl Mirapexin a 0,52mg 1 ujutru old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 25 individuals with a value less than 0.6 were subsequently diagnosed with PD. That is, 59.52% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.6 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 40, 'TN': 30, 'TP': 2, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 18, 'TN': 14, 'TP': 24, 'FP': 16}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 24, 'TN': 16, 'TP': 18, 'FP': 14}

Test Battery Details

Circle

numCircles 9
timePerCircleMean 33.12
timePerCircleCoV 0.184155
timePerCircleSlope -0.0643317
meanError 1.05872
tremorFreq 5.56641
tremorRelPower 27.739
tremorGyroAmpMean 0.0115147
tremorGyroAmpSlope 0.000370763
tremorGyroAmpCoV 0.385008
tremorCoordAmpMean 0.029811
tremorCoordAmpSlope 1.65948e-05
tremorCoordAmpCoV 0.314968
tremorAccAmpMean 0.0475347
tremorAccAmpSlope -5.38814e-05
tremorAccAmpCoV 0.128056
tremorPcRelVar 0.656502
tremorPcX 0.926853
tremorPcY -0.375425

Circle Segment 1

Duration 42.24 s, Accuracy Estimate 1.123 (lower is better)

Circle Segment 2

Duration 42.12 s, Accuracy Estimate 0.888 (lower is better)

Circle Segment 3

Duration 35.76 s, Accuracy Estimate 0.846 (lower is better)

Circle Segment 4

Duration 32.8 s, Accuracy Estimate 0.969 (lower is better)

Circle Segment 5

Duration 31.36 s, Accuracy Estimate 0.892 (lower is better)

Circle Segment 6

Duration 31.96 s, Accuracy Estimate 1.168 (lower is better)

Circle Segment 7

Duration 29.36 s, Accuracy Estimate 1.303 (lower is better)

Circle Segment 8

Duration 28.8 s, Accuracy Estimate 1.322 (lower is better)

Circle Segment 9

Duration 23.68 s, Accuracy Estimate 1.017 (lower is better)

Spiral

numSpirals 4
timePerSpiralMean 69.23
timePerSpiralCoV 0.248662
timePerSpiralSlope -0.188531
meanError 1.61236
tremorFreq 5.66406
tremorRelPower 30.3795
tremorGyroAmpMean 0.011952
tremorGyroAmpSlope 0.00113563
tremorGyroAmpCoV 0.398602
tremorCoordAmpMean 0.0321196
tremorCoordAmpSlope 0.000811796
tremorCoordAmpCoV 0.348055
tremorAccAmpMean 0.0835057
tremorAccAmpSlope 9.56893e-05
tremorAccAmpCoV 0.0635265
tremorPcRelVar 0.664075
tremorPcX 0.913888
tremorPcY 0.405965

Spiral Segment 1

Duration 91.96 s, Accuracy Estimate 1.363 (lower is better)

Spiral Segment 2

Duration 70.72 s, Accuracy Estimate 1.521 (lower is better)

Spiral Segment 3

Duration 63.32 s, Accuracy Estimate 1.707 (lower is better)

Spiral Segment 4

Duration 50.92 s, Accuracy Estimate 1.857 (lower is better)

Elel

eDurationMean 0.49246
eDurationStd 0.171408
eDurationStdnorm 0.348064
eDurationMedian 0.445
eDurationQuartdelta 0.2375
eDurationQuartdeltanorm 0.533708
eDurationKurt 3.58994
eDurationTrenddiff -0.23
eDurationTrendratio 0.613445
eWidthMean 4.85829
eWidthStd 1.85051
eWidthStdnorm 0.380898
eWidthMedian 4.68
eWidthQuartdelta 2.7495
eWidthQuartdeltanorm 0.5875
eWidthKurt 2.42861
eWidthTrenddiff -1.638
eWidthTrendratio 0.695652
eHeightMean 5.82586
eHeightStd 2.01022
eHeightStdnorm 0.345051
eHeightMedian 6.084
eHeightQuartdelta 3.24675
eHeightQuartdeltanorm 0.533654
eHeightKurt 2.64536
eHeightTrenddiff -2.808
eHeightTrendratio 0.59322
eAspectMean 0.858419
eAspectStd 0.256789
eAspectStdnorm 0.299142
eAspectMedian 0.828571
eAspectQuartdelta 0.29877
eAspectQuartdeltanorm 0.360585
eAspectKurt 4.39586
eAspectTrenddiff 0.195055
eAspectTrendratio 1.25357
eSlantMean 0.288293
eSlantStd 0.416947
eSlantStdnorm 1.44626
eSlantMedian 0.241935
eSlantQuartdelta 0.53485
eSlantQuartdeltanorm 2.21071
eSlantKurt 2.73652
eSlantTrenddiff 0.361305
eRtopMean 0.853194
eRtopStd 0.1437
eRtopStdnorm 0.168426
eRtopMedian 0.896552
eRtopQuartdelta 0.184267
eRtopQuartdeltanorm 0.205529
eRtopKurt 5.70728
eRtopTrenddiff 0.065
eRbotMean 0.590234
eRbotStd 0.46196
eRbotStdnorm 0.782673
eRbotMedian 0.533333
eRbotQuartdelta 0.485261
eRbotQuartdeltanorm 0.909864
eRbotKurt 5.83055
eRbotTrenddiff -0.328549
eRrightMean 0.895431
eRrightStd 0.116659
eRrightStdnorm 0.130282
eRrightMedian 0.935484
eRrightQuartdelta 0.115642
eRrightQuartdeltanorm 0.123618
eRrightKurt 4.77087
eRrightTrenddiff 0.0344612
eRleftMean 0.258343
eRleftStd 0.148861
eRleftStdnorm 0.576214
eRleftMedian 0.203704
eRleftQuartdelta 0.151394
eRleftQuartdeltanorm 0.743208
eRleftKurt 2.7737
eRleftTrenddiff -0.0783519
lDurationMean 0.665778
lDurationStd 0.320768
lDurationStdnorm 0.481794
lDurationMedian 0.57
lDurationQuartdelta 0.27125
lDurationQuartdeltanorm 0.475877
lDurationKurt 7.08722
lDurationTrenddiff -0.2075
lDurationTrendratio 0.708772
lWidthMean 9.308
lWidthStd 2.53436
lWidthStdnorm 0.272278
lWidthMedian 9.477
lWidthQuartdelta 3.83175
lWidthQuartdeltanorm 0.404321
lWidthKurt 2.15257
lWidthTrenddiff 2.691
lWidthTrendratio 1.36508
lHeightMean 14.9292
lHeightStd 2.831
lHeightStdnorm 0.189628
lHeightMedian 15.093
lHeightQuartdelta 3.861
lHeightQuartdeltanorm 0.255814
lHeightKurt 2.47455
lHeightTrenddiff -0.351
lHeightTrendratio 0.976834
lAspectMean 0.62884
lAspectStd 0.144047
lAspectStdnorm 0.229067
lAspectMedian 0.613636
lAspectQuartdelta 0.215835
lAspectQuartdeltanorm 0.351731
lAspectKurt 2.1549
lAspectTrenddiff 0.15621
lAspectTrendratio 1.28134
lSlantMean 0.370558
lSlantStd 0.204542
lSlantStdnorm 0.551985
lSlantMedian 0.384615
lSlantQuartdelta 0.276672
lSlantQuartdeltanorm 0.719348
lSlantKurt 2.77583
lSlantTrenddiff 0.18568
lRtopMean 0.907502
lRtopStd 0.140289
lRtopStdnorm 0.154588
lRtopMedian 0.944954
lRtopQuartdelta 0.0733611
lRtopQuartdeltanorm 0.0776346
lRtopKurt 25.0183
lRtopTrenddiff 0.0419442
lRbotMean 0.355752
lRbotStd 0.184475
lRbotStdnorm 0.518551
lRbotMedian 0.333333
lRbotQuartdelta 0.285801
lRbotQuartdeltanorm 0.857404
lRbotKurt 2.6057
lRbotTrenddiff -0.166803
lRrightMean 0.938564
lRrightStd 0.0625581
lRrightStdnorm 0.066653
lRrightMedian 0.957746
lRrightQuartdelta 0.0649124
lRrightQuartdeltanorm 0.0677762
lRrightKurt 4.38708
lRrightTrenddiff 0.0337512
lRleftMean 0.187317
lRleftStd 0.134097
lRleftStdnorm 0.715879
lRleftMedian 0.155844
lRleftQuartdelta 0.0940144
lRleftQuartdeltanorm 0.603259
lRleftKurt 15.0286
lRleftTrenddiff -0.0564053

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.717342
sumTouchScores 7.89076
meanMovementTime 1.9855
numTouches 11
undershootPercentage 0
overshootPercentage 45.4545

FITTS Long Modified

meanTouchScore 0.898747
sumTouchScores 8.08872
meanMovementTime 2.05
numTouches 9
undershootPercentage 0
overshootPercentage 33.3333

ZigZag

numZigzags 5
timePerZigzagMean 47.192
timePerZigzagCoV 0.201552
timePerZigzagSlope -0.12375
meanError 2.24493
tremorFreq 5.27344
tremorRelPower 31.0272
tremorGyroAmpMean 0.0171607
tremorGyroAmpSlope 0.00121367
tremorGyroAmpCoV 0.520138
tremorCoordAmpMean 0.0520517
tremorCoordAmpSlope 0.00166367
tremorCoordAmpCoV 0.399976
tremorAccAmpMean 0.046505
tremorAccAmpSlope 0.00094972
tremorAccAmpCoV 0.478221
tremorPcRelVar 0.620397
tremorPcX -0.822207
tremorPcY -0.569189

ZigZag Segment 1

Duration 57.48 s, Accuracy Estimate 1.95 (lower is better)

ZigZag Segment 2

Duration 52.64 s, Accuracy Estimate 2.037 (lower is better)

ZigZag Segment 3

Duration 49.32 s, Accuracy Estimate 2.149 (lower is better)

ZigZag Segment 4

Duration 43.84 s, Accuracy Estimate 2.56 (lower is better)

ZigZag Segment 5

Duration 32.68 s, Accuracy Estimate 2.529 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 18.656
timePerZigzagCoV 0.218389
timePerZigzagSlope -0.0962693
zigzagHeightMean 82.1799
zigzagHeightCoV 0.162116
zigzagHeightSlope 0.0679747
meanError 0.0899933
tremorFreq 6.93359
tremorRelPower 29.5083
tremorGyroAmpMean 0.0213921
tremorGyroAmpSlope 0.000615232
tremorGyroAmpCoV 0.367441
tremorCoordAmpMean 0.0736103
tremorCoordAmpSlope 0.00318763
tremorCoordAmpCoV 0.376631
tremorAccAmpMean 0.0433626
tremorAccAmpSlope 0.00135178
tremorAccAmpCoV 0.378755
tremorPcRelVar 0.773127
tremorPcX 0.00528437
tremorPcY -0.999986

ZigZag Offset Segment 1

Duration 25.64 s, Accuracy Estimate 0.144 (lower is better)

ZigZag Offset Segment 2

Duration 15.8 s, Accuracy Estimate 0.06 (lower is better)

ZigZag Offset Segment 3

Duration 18.76 s, Accuracy Estimate 0.086 (lower is better)

ZigZag Offset Segment 4

Duration 17.04 s, Accuracy Estimate 0.066 (lower is better)

ZigZag Offset Segment 5

Duration 16.04 s, Accuracy Estimate 0.094 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.6}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.6}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.099818157565976}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8342003077330651}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7137867214078727}